(131) Platelet Rich Plasma: Evaluation of Growth Factor Concentration in Men with ED

Abstract Introduction Platelet Rich Plasma (PRP) is a novel restorative therapy rich in growth factors and cytokines used to target the underlying causes of erectile dysfunction (ED). It not known, however, if composition PRP varies between men. Objective This study aimed evaluate factor variability among men with ED. Methods Whole blood was collected from sixteen men, eight participants at least six-month history The others were control group, including seven Peyronie’s Disease (PD) one healthy man without sexual dysfunction. extracted whole using Arthrex Angel system. A Human Growth Factor Antibody Array for 41 proteins performed. Using all 16 samples, quantitative detection GM-CSF, VEGF, TGF-β validated by western blot. Results From array, two - Granulocyte-Macrophage Colony Stimulating (GM-CSF) Transforming Factor-beta (TGF-β) identified as having 1.5-fold decrease control. In addition shortlisted factors, VEGF selected because androgens can upregulate production. Other than weak negative correlation expression age, we found no GM-CSF or BMI, comorbidities. Conclusions concentration appears vary Depending on individual concentration, treatment ED may need be personalized patients. Disclosure Any authors act consultant, employee shareholder an industry for: Acerus Pharmaceuticals, Boston Scientific, Coloplast, Endo Empower Pharmacy, Nestle Health, Olympus, Hims, Inc.